Symbol
Name
ID

Cxcr2
C-X-C motif chemokine receptor 2
MGI:105303

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Purpura
Disease(s) Associated with CXCR2	Purpura
IgA glomerulonephritis

Mouse Phenotypes

hematopoietic system phenotype

abnormal granulocyte differentiation

impaired neutrophil chemotaxis

decreased thymus weight

enlarged spleen

increased spleen weight

decreased immature B cell number

decreased pre-pro B cell number

abnormal myelopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

increased eosinophil cell number

decreased mean corpuscular hemoglobin

increased red blood cell distribution width

increased neutrophil cell number

increased granulocyte number

thrombocytosis

increased CD103-positive CD11b-low dendritic cell number

decreased mature B cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased memory-marker NK cell number

increased CD4-positive, alpha-beta memory T cell number

increased KLRG1+ CD4 alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

increased KLRG1+ CD8 alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased memory-marker CD4-positive NK T cell number

increased effector memory T-helper cell number

increased memory-marker gamma-delta T cell number

increased gamma-delta T cell number

decreased T cell number

increased Ly6C high monocyte number

increased Ly6C low monocyte number

increased monocyte cell number

increased leukocyte cell number

decreased spleen weight

abnormal spleen white pulp morphology

abnormal leukocyte physiology

abnormal eosinophil physiology

abnormal neutrophil physiology

impaired neutrophil recruitment

increased IgE level

abnormal T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal NK T cell physiology

Availability

Mouse Genotype

Cxcr2^{tm1(IL8RB)Dktr}/Cxcr2^{tm1(IL8RB)Dktr}

Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2^{tm1a(EUCOMM)Wtsi}

Cxcr2^tm1Mwm/Cxcr2^tm1Mwm

Cxcr2^tm1Mwm/Cxcr2⁺

Cxcr2^tm1Rmra/Cxcr2^tm1Rmra
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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